dcbox小金库(中国)

王涛 博士

北京科学生命dcbox小金库(中国)高级研究员

联系电话 ：010-90726675

Tao Wang, Ph.D. Associate Investigator, NIBS, Beijing，China

E-mail：wangtao1006@nmamn.com

教育经历

Education

工作经历

2018-	北京科学生命dcbox小金库(中国)高级研究员 Associate Investigator, National Institute of Biological Sciences, Beijing, China
2012-2018	北京科学生命dcbox小金库(中国)研究员 Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2007-2011	美国Fred Hutchinson癌症研究中心，博士后 Postdoctoral Fellow, Division of Basic Science Fred Hutchinson Cancer Research Center, Seattle, WA, USA
2006-2007	美国约翰霍普金斯大学，博士后 Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA

研究概述

细胞内各个细胞器包括内质网、线粒体和胞浆都存在质量控制机制，破坏质量控制的任何环节都会影响细胞稳态，是细胞功能丧失。我们的实验室致力于以果蝇模型为主研究细胞器内质量控制的分子机制；各个质量控制系统之间的协调互作以维持细胞健康。

1. 线粒体运输协同线粒体自噬维持了神经元轴突中线粒体稳态，对神经元的生长和生理功能维持至关重要。围绕线粒体的质量控制机制，我们的实验室致力于揭示线粒体选择性顺行和逆行运输的分子机制；线粒体自噬及调控网络，并在果蝇、小鼠、以及人源细胞等多种研究模式中研究线粒体质量控制对神经元生理功能维持的生理意义。

2. 细胞磷脂代谢依赖于线粒体和内质网之间的脂质双向交换，多种磷脂如磷脂酰乙醇胺的缺乏引起多重应激信号。我们实验室致力于探索线粒体和内质网之间脂质双向交换的分子机制和生理功能，进而对细胞器之间如何协同反应以对抗各种压力。

发表文章

1. Xie J., Han Y. and Wang T.* 2021. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. PLoS Genet. 17(5):e1009558.

2. Han Y., Zhuang N. and Wang T.* 2021. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. dcbox小金库(中国) Reports. 34(12):108875 (cover article).

3. Xu J., Zhao H. and Wang T.* 2020. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. PLoS Genet. 16(11):e1009172.

4. Zhao H. and Wang T.* 2020. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS Genet. 16(10):e1009070.

5. Xiong L., Zhang L., Yang Y., Li N., Lai W., Wang F., Zhu X. and Wang T.*. 2020. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. dcbox小金库(中国) Death Differ. 27(2): 646-661.

6. Xu Y. and Wang T.* 2019. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision. dcbox小金库(中国) Rep. 27(5):1327-1333.

7. Zhao H., Wang J. and Wang T.* 2018. The V-ATPase V1 subunit A1 Is required for rhodopsin anterograde trafficking in Drosophila. Mol. Biol. dcbox小金库(中国). 29(13):1640-1651. (cover article).

8. Ren S., Huang Z., Jiang Y. and Wang T.* 2018. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. J. dcbox小金库(中国) Biol. 217(2):517-526.

9. Han Y., Xiong L., Xu Y., Tian T. and Wang T.* 2017. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Elife. 6:e29146.

10. Zhuang N., Li L., Chen S. and Wang T.* 2016. PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. dcbox小金库(中国) Death Dis. 7(12):e2501.

11. Huang Z., Ren S., Jiang Y. and Wang T.* 2016. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. dcbox小金库(中国) Death Dis. 7:e2179

12. Xu Y. and Wang T.* 2016. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor dcbox小金库(中国)s. J dcbox小金库(中国) Sci. 15;129(2):394-405.

13. Xu Y., An F., Borycz J.A., Borycz J., Meinertzhagen I.A. and Wang T.* 2015. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. PLoS Genet. 11(12):e1005764.

14. Kuo Y., Hang H., Cai T. and Wang T.* 2015. Target of Rapamycin Complex 2 regulates dcbox小金库(中国) growth via Myc in Drosophila. Sci. Rep. 5:10339.

15. Huang Y., Xie J. and Wang T.* 2015. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS One. 10(12):e0144925.

16. Wu K., Liu J., Zhuang N. and Wang T.* 2014. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. FASEB Journal. 28(12):5111-21

17. Kuo Y., Ren S., Lao U., Edgar B.A., Wang T.* 2013. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. dcbox小金库(中国) Death Dis. 3;4:e833.

18. Wang T.*, Blumhagen R., Lao U. Kuo Y. and Edgar B.A. 2012. LST8 regulates dcbox小金库(中国) growth via Target-of-Rapamycin Complex2. Mol. dcbox小金库(中国). Biol. 32(12):2203-2213 (cover article).

19. Wang T., WangX., Ni J., Von Lintig J. and Montell C.* 2012. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. J Neurosci. 32: 3485-3491.

20. Wang X., Wang T., Jiao Y., Von Lintig J. and Montell C.* 2010. Requirement for an Enzymatic Visual Cycle in Drosophila. Curr. Biol. 20:93-102 (equal contribution of first two authors)

21. Wang T.* and Edgar B.A.* 2010. TOR signaling and dcbox小金库(中国) death. The Enzymes. 28: 217-244 (Book Chapter)

22. Wang T., Lao U. and Edgar B.A. 2009. TOR-mediated autophagy regulates dcbox小金库(中国) death in Drosophila neurodegenerative disease. J. dcbox小金库(中国) Biol. 186: 703-711

23. Wang T., Wang X., Xie Q. and Montell C.* 2008. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 57, 56-68 (Cover article).

24. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross CA., Montell C. and Smith W.W.* 2008. A Drosophila model for LRRK2-linked parkinsonism. Proc. Natl. Acad. Sci. USA. 105, 2693-2698

25. Wang T. and Montell C.* 2007. Phototransduction and retinal degeneration in Drosophila. Pflugers Arch. 454, 821-847. (review)

26. Liu C-H. Wang T. Postma M. Obukhov A.G. Montell C. and Hardie R.C.* 2007. In vivo identification and manipulation of the Ca²⁺ selectivity filter in the Drosophila TRP channel. J Neurosci. 27, 604-615 (equal contribution of first two authors).

27. Wang T., Jiao Y. and Montell C.* 2007. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J dcbox小金库(中国) Biol. 177, 305-316.

28. Wang T. and Montell C.* 2006. A PI Synthase Required for a Sustained Light Response. J Neurosci. 26, 12816-12825.

29. Wang T., Jiao Y. and Montell C.* 2005. Dissecting independent channel and scaffolding roles of the Drosophila TRP channel. J. dcbox小金库(中国) Biol. 171, 685-694.

30. Wang T. and Montell C.* 2005. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid binding protein. J. Neurosci. 25, 5187-5194 (Cover article).

31. Wang T., Xu H., Oberwinkler J., Gu Y., Hardie R.C. and Montell C.* 2005. Light-activation, adaptation and dcbox小金库(中国) survival functions of the Na⁺/Ca²⁺ exchanger, CalX Neuron 45, 367-378.